I installed pydio server on IIS.
Both web pages and ios can access and sync files.
But not on the windows client.
could you try with the address:port instead of domain name.
I use ddns instead of ip address.
when you installed it did you use an ip for the server ( and i yes, you should try with this ip)
Did you enable Pydio Root/web.config.sample to Pydio Root/web.config to enable some rewrite rules ?